Publications
 


Mechanical measurement of hydrogen bonded host-guest systems under non-equilibrium, near-physiological conditions (Highlighted in Chemistry World)
Teresa Naranjo, Fernando Cerron, Belén Nieto-Ortega, Alfonso Latorre, Álvaro Somoza, Borja Ibarra, Emilio M Perez
Chem. Sci., 2017,8, 6037-604.

Recent advances in uveal melanoma treatment
Beatriz Álvarez‐Rodríguez, Alfonso Latorre, Christian Posch, Álvaro Somoza
Med Res Rev. 2017;00:1-21. https://doi.org/10.1002/med.21460
Link

Oligonucleotide Sensor Based on Selective Capture of Upconversion Nanoparticles Triggered by Target-Induced DNA Interstrand Ligand Reaction
Diego Mendez-Gonzalez, Marco Laurenti, Alfonso Latorre, Alvaro Somoza, Ana Vazquez, Ana Isabel Negredo, Enrique López-Cabarcos, Oscar G Calderón, Sonia Melle, Jorge Rubio-Retama
ACS Appl. Mater. Interfaces, 2017, 9, 112272-12281.

Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers  (Highlighted in Biofísica Magazine)
Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez‐García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo‐Ochoa
Angew. Chem. In. Ed. 2017, 56, 987-991.
Link

Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence (Highlighted in Biofísica Magazine)
Siamak Javani, Romina Lorca, Alfonso Latorre, Cristina Flors, Aitziber L. Cortajarena, and Álvaro Somoza
ACS Appl. Mater. Interfaces, 2016, 8, 10147–10154.

Modified RNAs in CRISPR/Cas9: An Old Trick Works Again  (Highlighted in Biofísica Magazine)
Alfonso Latorre, Ana Latorre, Álvaro Somoza
Angew. Chem. In. Ed. 2016, 55, 3548–3550.
Link

Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.

Antonio Aires, Sandra M Ocampo, Bruno M Simões, María Josefa Rodríguez, Jael F Cadenas, Pierre Couleaud, Katherine Spence, Alfonso Latorre, Rodolfo Miranda, Álvaro Somoza, Robert B Clarke, José L Carrascosa, Aitziber L Cortajarena.
Nanotechnology 2016, 27, 065103.
Link

Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva, Álvaro Somoza, Aitziber L Cortajarena, Rodolfo Miranda, Ingrid Hilger
Breast Cancer Research 2015, 17, 1-17.
Link

Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers
Maria Tintoré, Stefania Mazzini, Laura Polito, Marcello Marelli, Alfonso Latorre, Álvaro Somoza, Anna Aviñó, Carme Fàbrega, Ramon Eritja
International journal of molecular sciences 2015, 16, 27625-27639.

Designed modular proteins as scaffolds to stabilize fluorescent nanoclusters  (Highlighted in Biofísica Magazine)
Pierre Couleaud, Sergio Adan-Bermudez, Antonio Aires, Sara H Mejías, Begoña Sot, Alvaro Somoza, Aitziber L Cortajarena
Biomacromolecules 2015, 16, 3836-3844.

Detection of GNAQ Mutations and Reduction of Cell Viability in Uveal Melanoma Cells with Functionalized Gold Nanoparticles
Christian Posch, Alfonso Latorre, Michelle B. Crosby, Anna Celli, Ana Latorre, Igor Vujic, Martina Sanlorenzo, Gary A. Green, Jingly Weier, Mitchell Zekhtser, Jeffrey Ma, Gabriela Monico, Devron H. Char, Denis Jusufbegovic, Klemens,Rappersberger, Álvaro Somoza, Susana Ortiz-Urda
Biomedical Microdevices 2015, 17, 1-9.

Glutathione-Triggered Drug Release From Nanostructures
Alfonso Latorre, Álvaro Somoza
Current Topics in Medicinal Chemistry 2014, 14, 2662-2671.

Multifunctionalization of magnetic nanoparticles for controlled drug release: a general approach
Alfonso Latorre, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, Álvaro Somoza
Eur. J. Med. Chem. 2014, 82, 355–362.

Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening
Miguel Garavís, Blanca López-Méndez, Alvaro Somoza, Julen Oyarzabal, Claudio Dalvit, Alfredo Villasante, Ramón Campos-Olivas, and Carlos González
ACS Chem. Biol., 2014, 9, 1559–1566


DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza
Nanoscale 2014, 6, 7436–7442.

Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures.
Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza.
Chem. Commun., 2014,50, 3018-3020


Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions
S. Pérez-rentero, A. Somoza, S. Grijalvo, B. Martin, I. G. Stará, I. Starý, R. Eritja
Journal of Chemistry Volume 2013 (2013), Article ID 650610, 11 pages
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Fluorescent DNA Stabilized Silver Nanoclusters as biosensors
Alfonso Latorre, Romina Lorca, Álvaro Somoza
Journal of Chemistry, Volume 2013 (2013), Article ID 631421, 6 pages
PDF

Enhanced Fluorescence of Silver Nanoclusters Stabilized with Branched Oligonucleotides.
Alfonso Latorre, Romina Lorca, Félix Zamora and Álvaro Somoza
Chem. Commun. 2013, 49, 4950

Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities.
Lourdes I. Cabrera, Álvaro Somoza, José F. Marco, Carlos J. Serna, M. Puerto Morales.
Journal of Nanoparticle Research, 2012, 14, 873.

DNA-mediated silver nanoclusters: synthesis, properties and applications.
Alfonso Latorre, Álvaro Somoza
ChemBioChem 2012, 13, 951–8.

Interstrand interactions on DNA duplexes modified by TTF units at the 3′ or 5′-ends.
S. Pérez-Rentero, I. Gállego, Á. Somoza, R. Ferreira, J. Janoušek, M. Bělohradský, I. G. Stará, I. Starý, R. Eritja
RSC Advances 2012, 2, 4069.

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development. Edited by Paul H. Johnson
Álvaro Somoza.
ChemMedChem 2011, 6, 1311–1312.

Modified siRNAs for the study of the PAZ domain
Álvaro Somoza, Montserrat Terrazas, Ramón Eritja.
Chemical Commun. 2010, 46, 4270–2

Modificaciones Químicas en ARN interferente : De la investigación básica a las aplicaciones terapéuticas.
Álvaro Somoza
Anales de Química, 2010, 106, 215-222.

Evolution of DNA origami.
Álvaro Somoza
Angew. Chem. Int. Ed. 2009, 48, 9406–8.
Link

Protecting groups for RNA synthesis: an increasing need for selective preparative methods (Selected for its inclusion in RSC’s Chemical Biology issue 1, 2009)
Álvaro Somoza
Chem. Soc. Rev., 2008,37, 2668-2675
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The Roles of Hydrogen Bonding and Sterics in RNA Interference (Hot Paper)
Alvaro Somoza, Jijumon Chelliserrykattil, Eric T. Kool
Angew. Chem. Int. Ed. 2006, 45, 4994–4997.



β-Hydroxysulfoxides as chiral cyclic ketone equivalents: enantioselective synthesis of polysubstituted cyclohexanones, cyclohexenones and cyclohexenediones
M. Carmen Carreño, Manuel Pérez-González, María Ribagorda, Álvaro Somoza, Antonio Urbano
Chem. Commun., 2002, 3052-3053.


Enantioselective Total Synthesis of Angucyclinone-Type Antibiotics Rubiginones A2 and C2
M. Carmen Carreño, María Ribagorda, Álvaro Somoza, Antonio Urbano
Angew. Chem. Int. Ed. 2002, 41, 2755–2757.